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Process Intelligence & Simulation Solutions

Understand the Process. Scale with Confidence.

Acuflow brings Tridiagonal Software’s advanced process-modeling and simulation platforms to pharmaceutical, biopharma and process-industry teams. From stirred-tank mixing analysis and automated CFD to AI-powered process intelligence, digital twins and decision-support applications, Tridiagonal helps engineers and scientists improve process development, scale-up, technology transfer and optimization.

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Tridiagonal Software

Our Solutions

Two Platforms. Different Questions. One Process-Intelligence Ecosystem.

MixIT

MixIT®

Stirred Tank Mixing Software

 SimSight

SimSight

AI-Powered Process Intelligence Platform

Product 1

MixIT®

Stirred Tank Mixing Software

MixIT is designed for stirred-tank process development, scale-up and troubleshooting. It combines process data, mixing science, empirical correlations and advanced 3D CFD models in one collaborative engineering platform.

MixIT

Features

  • Intuitive engineering GUI
  • Shared reactor database
  • Empirical correlations
  • Complex impeller library
  • Fully automated CFD analysis
  • Vortex-shape prediction
  • Reports and visualization
  • Reactor / process tagging
  • Multiple turbulence models
  • Custom correlation capability
  • Custom baffles and internals
  • Fluid-rheology analysis
  • Lab-to-plant process-data integration
  • Enterprise knowledge sharing
  • Available through MixIT Enterprise and MixIT On Cloud pathways

MixIT Technical Capabilities

CapabilityTechnical Function
Reactor DatabaseStore geometry, operating conditions, plant measurements, experimental results and CFD data
Reactor AnalysisCompare multiple reactors and evaluate mixing performance
Automated CFDAutomated geometry creation, simulation, analysis and reporting
Flow AnalysisEvaluate velocity patterns and circulation behavior
Tracer AnalysisStudy mixing and residence-time behavior
Heat TransferAnalyze thermal performance in stirred vessels
Impeller AnalysisEvaluate multiple impeller geometries and configurations
Vortex PredictionPredict vortex shape and free-surface effects
Fluid RheologyModel Newtonian and non-Newtonian fluids
Scale-Up AnalysisCompare conditions across reactor scales
ReportingGenerate engineering reports and visualizations

MixIT Applications

Process / Unit OperationAnalysis
BlendingMixing Time
Solid-Liquid OperationsSolid Suspension | Cloud Height | Njs
CrystallizationMeso-Mixing | Particle Size Distribution | Heating / Cooling | Anti-Solvent Mixing
FermentationEnergy Dissipation | Volumetric Mass Transfer | Oxygen Transfer
HydrogenationBubble Size | Gas Distribution | Entrainment
EmulsificationShear Rate | Energy Dissipation | Droplet Size Distribution
BioreactorsNutrient Mixing | Gas Distribution | Bubble Size | Strain Rate
ExtractionDroplet Size | Circulation Time
PolymerizationParticle Size Distribution | Heat Transfer | P/V
Chlorination / NitrationBubble Size | Gas Distribution | Entrainment

Product 2

SimSight

AI-Powered Process Intelligence Platform

SimSight blends physics-based simulation, historical process data and advanced analytics to accelerate process development, scale-up, monitoring and optimization. It provides an environment for equipment knowledge, process models, visualization and reusable decision-support applications.

SimSight

Features

  • Physics-based process models
  • Historical process-data integration
  • Advanced analytics
  • Knowledge database
  • Asset / equipment library
  • Process-parameter analysis
  • Process-metric analysis
  • Scenario comparison
  • Flow and mixing visualization
  • Custom decision-support apps
  • Browser-enabled application environment
  • Python / Jupyter app deployment
  • Reusable process knowledge
  • Customizable enterprise workflows
  • Digital twin and hybrid-modeling workflows

SimSight Technical Capabilities

CapabilityTechnical Function
Knowledge DatabaseStore and retrieve fundamental equipment and process knowledge
Asset LibraryOrganize reusable knowledge about process equipment
AnalyzeEvaluate scale-up, process-transfer and operating scenarios
ExploreStudy relationships between process parameters and process metrics
CurateBuild reusable libraries of assets, SUBs, SUMs and process knowledge
DeployDevelop and deploy browser-enabled Python / Jupyter applications
VisualizeCompare flow and mixing behavior across process conditions
Hybrid ModelingCombine physics-driven and data-driven approaches
Historical Data AnalyticsIdentify patterns and trends from prior operating data
Decision SupportConvert models and knowledge into repeatable engineering workflows

SimSight Applications

ApplicationPurpose
Bioreactor Scale-UpUnderstand how the internal equipment environment changes across scales and support comparable process conditions.
Process Scale-UpSupport consistent process performance from lab through production.
Blend-Time PredictionPredict blend-time performance rapidly across operating conditions.
CrystallizationPredict particle-size distribution and support process-condition evaluation.
Mass-Transfer AnalysisEvaluate and optimize kLa and related mass-transfer behavior.
Reduced-Order ModelsGenerate faster predictions of complex flow fields for repeated engineering use.
Process TransferCompare equipment and process conditions to support technology transfer.
Equipment DigitalizationCapture vessel characteristics, engineering models and process knowledge digitally.

Where Tridiagonal Fits

Across the Process Lifecycle

Process Development Equipment Selection Design & Optimization Scale-Up Technology Transfer Manufacturing Support Continuous Improvement

Why Tridiagonal Software?

  • Built around process engineering, modeling and simulation.
  • Specialized platforms for design, scale-up, optimization, technology transfer and troubleshooting.
  • Combines engineering science with CFD, process data and advanced analytics.
  • Supports multiple process-industry environments including Pharma, BioPharma, Chemicals, CPG, Oil & Gas and OEM.

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